NF Malaysia

Providing Support to Patients, Families, and Friends of Neufibromatosis

The plight of NF patients in Malaysia

March 1st, 2007 by Yvonne

Pelf very kindly reminded me to update this website which i have abandoned for some time. Many apologies. There are so many concerns needing my attention everyday, it’s hard to remain focused on spreading awareness on NF.

Sometimes, when people realize that I overspend on any one occasion, some would undeniably wonder if I am needy at all. I need money for medical treatment, money for college, money for survival, money to gain knowledge, money to help other people, what else? But that is life. We are not computer softwares programmed to deal with NF 24/7.

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CTF research identifies new regulators of tumor suppression

July 9th, 2006 by Yvonne

Major breakthrough for Neurofibromatosis Type 1.

June 22nd, 2006: A team of Duke University and Scripps Clinic researchers that includes a Children’s Tumor Foundation Young Investigator Awardee has identified two novel proteins that play a key role in regulating normal function of neurofibromin, the product of the neurofibromatosis type 1 (Nf1) gene.

These proteins, named Gpb1 and Gbp2, are described as a ‘molecular brake’ system, and appear to be critical in the normal tumor suppression function of neurofibromin. In NF1, the disruption of tumor suppression leads to the formation of tumors such as dermal neurofibromas, plexiform neurofibromas and optic gliomas. These newly identified genes therefore may represent future candidate drug targets for NF1 tumor treatment.

Dr. Toshaki Harashima, a Children’s Tumor Foundation 2004-2006 Young Investigator Awardee, says “our findings add to basic understanding of how neurofibromin is stabilized. By shedding light on these fundamental processes, we hope we can help in the development of new drugs or therapies to block the activation of Ras and prevent this disease.”

The studies were conducted in yeast, and can be readily translated to humans since signaling processes and genes are highly conserved between the two.

The researchers findings are published in the June 23, 2006, issue of the journal Molecular Cell

For the Duke University press release, click here.

Source: CTF.ORG

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NFMALAYSIA hosted on its own!

July 9th, 2006 by Yvonne

Yay! The blog is finally shifted! Many thanks to my host, Mercumaya, for the free upgrade. The url, “www.nfmalaysia.org” is no longer forwarded to nf.yvonnefoong.com, but hosted on its own! Isn’t that great? This means better google ranking and search engine catche!

Now, it’s time to tweak the layout a little. Till then!

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Upgrading webspace for better blogging

July 6th, 2006 by Yvonne

Ugh…. this weblog is so ugly, don’t you agree? I’m so sorry people, but I’ve been bogged down by my many commitments and failed to take good care of this blog.

I should have, considering that this blog receives most publicity since the url is printed on every HEART4HOPE t-shirt. My bad. I can imagine when a new buyer decides to surf this website, he’d be immediately turned off by the lack of updates.

Time to pick up the pieces now. I’m gonna upgrade my hosting package so that we may personally host the domain www.nfmalaysia.org. It’s good for SEO (search engine optimisation). Don’t know what SEO is? Errr… ask google. Upgrading the package will also allow me to have multiple MgSQL databases, so I will no longer have to cram 3 blogs into one database. I was stingy, but had no choice. Don’t laugh! I think akismet would also work better when the blogs are properly organised that way. Without akismet, this blog became a spam junkyard. Urrggghhh!!!

Ok that’s all now. I have my webhost on MSN. isn’t that cool? Will discuss with him and hopefully, get this thing settled in another day or two. Maybe I should invite guestbloggers. Maybe the folks at Segi College who are always so gung ho at championing HEART4HOPE. They are awesome!

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Site revamping

March 31st, 2006 by Yvonne

Good grief. After months of searching, I finally found someone to help redesign the layout of this site at low cost. Freelancing is a tough job to survive, and website designers charge a fortune nowadays.

Being the poor non-profit organisation as we are, we have little to splash on big-time designers. Fortunately, someone’s willing to sacrifice a meal or two to aid our mission.

The money’s gonna be out from my pocket, but it will be all worthwhile. After all, this url appears on HEART4HOPE t-shirts, so we need to be more presentable. Don’t we?

Just a little insider now. The layout’s gonna be of old-school coding, and not on some blogging system that’s becoming so common these days. Instead of just displaying our identity, the new site will be our medium to communicate with the public. It’ll have many articles conitributed by NF sufferers worldwide and feedbacks will be strongly encouraged! It’s gonna be happening!

On another note, we’ve got a brilliant idea on how the new design for my t-shirt will be, an even stronger message and theme this time. Whhheeee!!

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Breakthrough for NF

January 28th, 2006 by Keisha Somasundram

Victims afflicted with NF 1, this is indeed a year for you to be jubilant! Scientists of University California Los Angeles a.k.a UCLA have discovered that statins, a prominent class of cholestrol drugs, can overcome mutations that cause learning disabilities. The FDA has approved drugs that are currently being tested on adults with NF 1 and children who are genetically affected with retardation.

NF 1 victims, unfortunately, fall prey to learning difficulties in speech and writing. So, this is massive for them. I’m chuffed, excited, and shocked at this new discovery. I applaud the scientists of UCLA once again for playing a leading role in the medical field!

This is a positive move in the right direction for a cure. To read the article. do visit:
UCLA Website

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Kirsty Ashton

January 23rd, 2006 by Yvonne

Here comes a touching and remarkable story of 15 year old Kirsty Ashton who suffers from Neurofibromatosis. She has recently been nominated for the Pride of Manchester award. Click here to read more.

In case if the Manchester evening news website removes that link, I quote the entire article…

TEENAGER Kirsty Ashton has battled with her own illness to show dedication to others through her tireless charity fundraising.

Now, in our search to find the most outstanding men and women in Greater Manchester, she has been nominated for the Pride of Manchester award, organised by the M.E.N. with Britannia Building Society.

Kirsty, 15, from Wythenshawe, has an incurable condition called Neurofibromatosis, which causes tumours throughout the body with a myriad of physical problems including a curvature of the spine, forcing her to wear a body brace.

But in two years, she has raised more than £4,000 for children’s charity When You Wish Upon A Star.

Website

She has set up a website to help others in a similar position and checked her web page every day for others who needed her help while she was in hospital.

She is studying for her GCSEs at Altrincham College of Art and plans to study Performing Arts and hopes to be an actress.

Kirsty was nominated by her brother Christopher.

Her mother Julie said: “It’s a great honour, she’s been through a lot and we don’t know how bad her condition will get as she gets older, but right now she is more concerned with her next fundraising event.”

The Pride of Manchester Award was launched to celebrate the unsung heroes and exceptional people in our area who make a difference to others’ lives. The winners and runners-up will get cash prizes of up to £3,000 to donate to a charity of their choice.

That’s about the Pirce of Manchester award. Now here comes another one… Click to read.

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Heart filled with Hope

January 22nd, 2006 by KG

Greetings everyone! My name is Kumaraguru Krishnan , or better known among my fellow friends as kG.I’m the most recent resident writer for NF Malaysia.My hopes and dreams are very high for NF Malaysia and I believe very much that they are achievable with the support of the public.You see, my education on NF wholly came from my soul mate Keisha who lives with NF 2. Our lifetime friendship saw her through many difficult surgeries and painfull experiences caused by NF.As the years grow, my awareness of NF with it.But it wasn’t until 3 years back that I took a keen interest in NF.Ever since, I have been learning and moving along with the updates on NF.

Very recently, I had the splendid pleasure of meeting Yvonne whom as you know lives with NF 2.It was not long before I learnt of her temporary disability to hear due to bilateral acoustic neuromas and her battle to raise the funds for her surgery.At that very point, there was nothing more inspiring than to know that she had pulled this whole fundraiser together ALL BY HERSELF.

That, was the takeoff point of my involvement in NF Malaysia.
It was simply breathtaking to know that I could ‘Do Something’ to help so many people out there .Every person is capable of contributing to this battle through NF.Whether you suffer from NF or otherwise, it always helps to be aware of it.

Raising awareness is one of the biggest moves one can make to help.It all begins here.Many cases and symptoms have already been dicussed in previous posts.Each and every detail in those documents are crucial to further understand NF.Other than growth of multiple tumors there are several other conditions that may trail up.Recognising and sighting them at early stages is something you can do being aware of NF.

NF can also cause skin changes, bone deformities and other problems. It can also cause developmental abnormalities; patients with NF have a higher incidence of learning disabilities.But then again, symptoms vary greatly. They generally get worse over time.

Some people have symptoms that are mild or not noticeable at all.
In other cases, NF significantly disables people. Such times call for your full support.
Learning disabilities affect about half of people with NF1. A child may have delays in learning to walk or talk. Some people also have mental retardation and/or speech problems; short stature and oversized head (macrocephaly); skeletal abnormalities such as enlarged/deformed bones and curvature of the spine (scoliosis); hypertension and an increased risk of cancer (malignancy).

Some people with NF and other genetic disorders become lonely and withdrawn because they feel different from others.
They may have emotional and/or social pain concerning their appearance. They may also fear complications, tumor growth or cancer. Many of these patients may wonder whether to have children.
Many parents of children diagnosed with NF also feel shock, anger, sadness, confusion, guilt and anxiety.
Family counseling and genetic counseling may help people with NF and their families. Counseling can provide support, answer questions and help you make plans for the future. People with NF may also want to attend support groups and stay informed about the latest medical research on neurofibromatosis.

With that ,I conclude my introductory post for NF Malaysia.I believe all of us can help to make ‘Project Heart4Hope’ a full success.So please buy a t-shirt and save a life. : )

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Merry Merry Merry Christmas And A Joyous Happy New Year!

December 24th, 2005 by Keisha Somasundram

Hello fellow Malaysians and other visitors of NF Malaysia, I wanted to wish all of you a Merry Christmas and a Happy New Year. I’m still flabbergasted at the thought of how fast this year has passed! It just feels like yesterday, I turned 16! This year has been full of ups and downs for me, but then again, isn’t life that way? This whole month has been crazy especially for one paticular reason! All I can say is what a finish to the year! I’m so excited, I’ve got a year and a half till I graduate and I’m hoping to score high on SAT so that I will be able to enter a good university in America. It is my dream to study there and I’m going to try very hard to gain admission into my dream university, UCLA.

As of next year, NF Malaysia is going to be registered as an NGO. We’re all ebullient about the project and we hope it will be a success. Once again, all credit given to Yvonne for her hard work! She has done a fantastic job for NF Malaysia, I just hope one day I can do the same!

Thank you all for supporting NF Malaysia. It means so much to us!

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DEPRESSION - CLOSE TO DEATH

December 11th, 2005 by Keisha Somasundram

Neurofibromatosis can be brutal, not just physically but emotionally. Feelings of loneliness, emptiness, anxiety, stress, chronic insomnia, suicide are some of the dark shadows that contribute to the NF predicament. Yes, we all have our dilemmas in life but in the case of NFers, we have to fear for the uncertainty of the future every single day of our lives. Most of we NFers agree that the physical pain cannot even be compared to the emotional trauma that we have to go through. There are always questions whirling around in our head.

1. “What’s going to happen to me if I become deaf or blind?”

2. “Am I going to be paralysed?”

3. “How am I suppose to be financially secure since NF will drain the last penny I have?”

4. “What is the longevity of an NF 1 or NF 2 patient?”

5. “How am I to pursue this career when NF is preventing me from doing so?”

6. “Will I ever have a normal relationship? Can I ever be loved unconditionally? Will they accept
me?”

7. “I can’t possibly have children can I? Since I would pass on the disease to the child, it seems
like the most selfish thing to do to a person.”

8. “Should I just end my misery now? It seems so simple.”

9. “What is my purpose in life, to suffer?”

10. “Why does society have to be so prejudice? Why can’t they accept me? Why do I seem like an
alien to them?”

11. “Why can’t I live a happy life? Why can’t I have someone to hold me when I feel at my lowest?”

These are just some of the burning questions that we face everyday. NF hinders our ability to pursue life to its fullest extent. Can you imagine life like a ticking time bomb? Ready to explode at any minute? The anxiety, the pain and not knowing where you’re going or what’s going to happen to you can result in a suicidal frame of mind. Believe me when I say, I’ve been there and done that. The worst part was not having ANYONE to turn to. I had no medication, no counselling, nothing.
I allowed NF to eat away into my soul, I gave it access to mold my heart into an angry one. I hated NF, I hated what it had done to me and I hated living in this world. I wanted to die. How easy would it have been if I just killed myself. No more pain, no more tears, no more loneliness. I would cry myself to sleep wondering what did I ever do to deserve this? My family are living healthy lives while I suffered in silence. My friends were going through many of life’s wonderful experiences while I was left in the dark. I feared for the worst everyday. Even as I write this, I feel the emotions running through my body. I was so angry at the world that I was determined to take out my anger on the people that were closest to me.

I have read about several depression cases on the main NF Board. It was quite clear that women were affected more by depression rather than men. Or do men like to bottle their feelings up? One of the NF members wrote this post (By the way, this is a man in his 40’s):

” I have suffered severe depression since early puberty cos of my NF. I have taken a overdose before and tried to hang myself (the hook on the door snapped)
I am still very suicidal and would take a pill that would kill me in my sleep without a second thought.
Is it fair that I have to live the life I never asked for in this world of war and hatred along with the uglyness and pain and uncertain future of nf and the restrictions and finance problems it brings me?

Is it not selfish of those around me to want me to live like this to say that I am the selfish one.

I think suicide is brave! I wish I could find a easy way out.

Please do not mention God to me! That makes me feel worse! Religion breeds intolerance half the worlds problems are religion, I do not believe in Gods/Devils/Heavens/Hells. What you see is what you get.”

It is pretty nasty, don’t you think? A few years back, I might have thought the same way. I did not believe in a God, my reasoning was, “if God was love, why bring upon the world such atrocities?” I could not think clearly. My mind seemed to be immersed in hatred for my faith and the people around me.

What changed my perspective? Certain people came into my life and showed me that life is so much more than just NF. “Instead of always complaining about what you don’t have, you should be thankful that you don’t get what you deserve.” This is a phrase which I live by everyday. I began to reevaluate my life. I looked at the things which I did have and I was thankful for it. I learned that NF will only defeat me if I LET IT. I do have kyphosis but I’m still walking aren’t I? The question that I used to ask was “If God was love, why bring upon the world such atrocities?” But now I realised the world’s problems are caused by us. We bring it upon ourselves and blame it on God which is unfair. Nothing can stop me from pursuing my dream so long as my faith remains. My faith is growing stronger everyday and my life seems so much happier. I believe my purpose in the world is to use my suffering to touch and make a difference in people’s lives. Spreading NF in Malaysia for one thing. There was an atheist named Bertrand Russell who once said, “Unless you assume a God, the question of life’s purpose is meaningless.”

A lot of NFers consume anti-depressants. I’m not going to fault them on that because most of them cannot handle the intense pressure that NF causes. Prozac is famous among them.

It’s definitely a slow process. I do have my days but then again, I do have friends like Yvonne who’s there for me when I need her. One step at a time, one little step at a time to a better life. And I do not take any drugs to numb the pain. I figured that life is what I make of it, not a pill!

DEPRESSIVE ILLNESSES

Research is ongoing into possible causes of depression and other mental illnesses. Studies examine the genetic and environmental risks for depression-both alone and when it occurs with other problems such as anxiety disorders. Several parts of the brain are under investigation. Using brain imaging technologies and neurochemical techniques, scientists are finding that a network of interacting structures is responsible for our emotions. NIMH says brain imaging research is revealing that in depression, neural circuits responsible for moods, thinking, sleep, appetite, and behavior fail to function properly, and that the regulation of critical neurotransmitters is impaired. Research is also looking into the role of the amygdala, an almond-shaped structure deep within the brain. The amygdala is believed to serve as a communications hub between the parts of the brain that process incoming sensory signals and the parts that interpret them.

NIMH also says that the the hypothalamic-pituitary-adrenal (HPA) axis, the hormonal system that regulates the body’s response to stress, is overactive in many people with depression. Research findings suggest that persistent overactivation of this system may lay the groundwork for depression. Other research focuses on the hippocampus, another brain structure that is responsible for processing stimuli. The hippocampus plays a key role in the brain by helping to encode information into memories. Scientists hope that greater understanding of the brain and how it works can lead to better understanding of depression and many other mental illnesses.

Treatment options
When depression alone is the problem, treatment options depend on the severity of the depression. NIMH says that in milder cases of depression, lifestyle changes, such as getting more exercise, can be helpful. If symptoms persist, however, behavioral therapy may be needed.
There are many forms of psychotherapy, some short-term, others conducted on more of an on-going basis. Talk therapists help patients gain insight into and resolve their problems through verbal exchanges. Behavioral therapists help patients learn how to gain more satisfaction from their activities and unlearn behavioral patterns that contribute to or result from their depression.
NIMH says two of the short-term psychotherapies that research has shown helpful for some forms of depression are interpersonal and cognitive/behavioral therapies. Interpersonal therapists focus on the patient’s disturbed personal relationships that both cause the depression and make it worse. Cognitive/behavioral therapists help patients change the negative styles of thinking and behaving that is often associated with depression. There are also psychodynamic therapies, which focus on resolving the patient’s conflicted feelings. These therapies are often reserved until the depressive symptoms are significantly improved.

Depression, however, can often require more extensive treatment, such as medications. This is most true for severe depressive illnesses, particularly those that are recurrent. NIMH says more extensive treatment can be used along with, or preceding, psychotherapy for the best outcome. According to the National Alliance for the Mentally Ill (NAMI), four groups of antidepressant medications have been used to treat depressive illness:

tricyclics

monoamine oxidase inhibitors or MAOIs

selective serotonin reuptake inhibitors or SSRI’s

norepinephrine and serotonin reuptake inhibitors or NSRIs

NIMH says that if medication is used, it’s most effective when combined with therapy, so that the medication can help provide symptom relief and psychotherapy can help the patient learn more effective ways to deal with life’s problems. It is also essential that anyone taking medications be aware of potential side effects. Some medications may interact with other medicine, or even with foods. Some medications can cause side effects that include dry mouth, weight gain and drowsiness. Other types of medications can lead to insomnia, restlessness, headache or more serious concerns. Any side effects should be reported at once. Medications should also be monitored carefully by the patient’s doctor.
NAMI says, once diagnosed, 80 percent of clinically depressed individuals can be effectively treated. The thing to remember is that in many cases of depression, it’s not possible to just “snap out of it.” That’s why it’s important to view depression as a real disorder and talk with a doctor about getting proper medical help if you’re concerned about depression in yourself or in someone you care for.

Source: Healthsteps

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